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Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides

Currently, gapmer antisense oligonucleotide (ASO) therapeutics are under clinical development for the treatment of various diseases, including previously intractable human disorders; however, they have the potential to induce hepatotoxicity. Although several groups have reported the reduced hepatoto...

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Detalles Bibliográficos
Autores principales:	Yoshida, Tokuyuki, Morihiro, Kunihiko, Naito, Yuki, Mikami, Atsushi, Kasahara, Yuuya, Inoue, Takao, Obika, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303313/ https://www.ncbi.nlm.nih.gov/pubmed/35801870 http://dx.doi.org/10.1093/nar/gkac562

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