Novel agonist and antagonist radioligands for the GLP‐2 receptor. Useful tools for studies of basic GLP‐2 receptor pharmacology

BACKGROUND: Glucagon‐like peptide‐2 (GLP‐2) is a pro‐glucagon‐derived hormone secreted from intestinal enteroendocrine L cells with actions on gut and bones. GLP‐2(1–33) is cleaved by DPP‐4, forming GLP‐2(3–33), having low intrinsic activity and competitive antagonism properties at GLP‐2 receptors....

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Detalles Bibliográficos
Autores principales: Gadgaard, Sarina, van der Velden, Wijnand J. C., Schiellerup, Sine P., Hunt, Jenna Elizabeth, Gabe, Maria B. N., Windeløv, Johanne Agerlin, Boer, Geke Aline, Kissow, Hannelouise, Ørskov, Cathrine, Holst, Jens J., Hartmann, Bolette, Rosenkilde, Mette M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303331/
https://www.ncbi.nlm.nih.gov/pubmed/34855984
http://dx.doi.org/10.1111/bph.15766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303331/
https://www.ncbi.nlm.nih.gov/pubmed/34855984
http://dx.doi.org/10.1111/bph.15766

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