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Practical approaches to labelling terminal alkynes with deuterium
Base catalysed exchange with sodium hydroxide, calcium oxide or N,N,N,N‐tetramethylguanidine in deuterium oxide is a viable procedure for the preparation of terminally deuterated alkynes for those alkynes stable to strong base. The use of silver perchlorate as a catalyst is an alternative practical...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303397/ https://www.ncbi.nlm.nih.gov/pubmed/35067956 http://dx.doi.org/10.1002/jlcr.3963 |
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author | Chan, Melanie Y. T. Anwar, Arbab Lockley, William J. S. |
author_facet | Chan, Melanie Y. T. Anwar, Arbab Lockley, William J. S. |
author_sort | Chan, Melanie Y. T. |
collection | PubMed |
description | Base catalysed exchange with sodium hydroxide, calcium oxide or N,N,N,N‐tetramethylguanidine in deuterium oxide is a viable procedure for the preparation of terminally deuterated alkynes for those alkynes stable to strong base. The use of silver perchlorate as a catalyst is an alternative practical option when labelling alkynes which are sensitive to base or contain functionalities which would lead to labelling elsewhere in the molecule. Labelling with this catalyst takes place smoothly at ambient temperature in a mixture of N,N‐dimethylformamide and deuterium oxide. |
format | Online Article Text |
id | pubmed-9303397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93033972022-07-22 Practical approaches to labelling terminal alkynes with deuterium Chan, Melanie Y. T. Anwar, Arbab Lockley, William J. S. J Labelled Comp Radiopharm Research Articles Base catalysed exchange with sodium hydroxide, calcium oxide or N,N,N,N‐tetramethylguanidine in deuterium oxide is a viable procedure for the preparation of terminally deuterated alkynes for those alkynes stable to strong base. The use of silver perchlorate as a catalyst is an alternative practical option when labelling alkynes which are sensitive to base or contain functionalities which would lead to labelling elsewhere in the molecule. Labelling with this catalyst takes place smoothly at ambient temperature in a mixture of N,N‐dimethylformamide and deuterium oxide. John Wiley and Sons Inc. 2022-02-02 2022-04 /pmc/articles/PMC9303397/ /pubmed/35067956 http://dx.doi.org/10.1002/jlcr.3963 Text en © 2022 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Chan, Melanie Y. T. Anwar, Arbab Lockley, William J. S. Practical approaches to labelling terminal alkynes with deuterium |
title | Practical approaches to labelling terminal alkynes with deuterium |
title_full | Practical approaches to labelling terminal alkynes with deuterium |
title_fullStr | Practical approaches to labelling terminal alkynes with deuterium |
title_full_unstemmed | Practical approaches to labelling terminal alkynes with deuterium |
title_short | Practical approaches to labelling terminal alkynes with deuterium |
title_sort | practical approaches to labelling terminal alkynes with deuterium |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303397/ https://www.ncbi.nlm.nih.gov/pubmed/35067956 http://dx.doi.org/10.1002/jlcr.3963 |
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