Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Properties

A series of hexafluoroisopropyl carbamates with indolylalkyl‐ and azaindolylalkyl‐substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). The synthesized derivat...

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Detalles Bibliográficos
Autores principales: Barth, Maximilian, Rudolph, Stefan, Kampschulze, Jan, Meyer zu Vilsendorf, Imke, Hanekamp, Walburga, Mulac, Dennis, Langer, Klaus, Lehr, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303458/
https://www.ncbi.nlm.nih.gov/pubmed/35072346
http://dx.doi.org/10.1002/cmdc.202100757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303458/
https://www.ncbi.nlm.nih.gov/pubmed/35072346
http://dx.doi.org/10.1002/cmdc.202100757

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