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Conditional power and friends: The why and how of (un)planned, unblinded sample size recalculations in confirmatory trials
Adapting the final sample size of a trial to the evidence accruing during the trial is a natural way to address planning uncertainty. Since the sample size is usually determined by an argument based on the power of the trial, an interim analysis raises the question of how the final sample size shoul...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303654/ https://www.ncbi.nlm.nih.gov/pubmed/35023184 http://dx.doi.org/10.1002/sim.9288 |