Excessive osteoclast activation by osteoblast paracrine factor RANKL is a major cause of the abnormal long bone phenotype in Apert syndrome model mice

The fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling pathway plays important roles in the development and growth of the skeleton. Apert syndrome caused by gain‐of‐function mutations of FGFR2 results in aberrant phenotypes of the skull, midface, and limbs. Although short limbs are represe...

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Detalles Bibliográficos
Autores principales: Shin, Hye‐Rim, Kim, Bong‐Soo, Kim, Hyun‐Jung, Yoon, Heein, Kim, Woo‐Jin, Choi, Je‐Yong, Ryoo, Hyun‐Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303724/
https://www.ncbi.nlm.nih.gov/pubmed/35048384
http://dx.doi.org/10.1002/jcp.30682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303724/
https://www.ncbi.nlm.nih.gov/pubmed/35048384
http://dx.doi.org/10.1002/jcp.30682

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