Structural Insights into Pixatimod (PG545) Inhibition of Heparanase, a Key Enzyme in Cancer and Viral Infections

Pixatimod (PG545), a heparan sulfate (HS) mimetic and anticancer agent currently in clinical trials, is a potent inhibitor of heparanase. Heparanase is an endo‐β‐glucuronidase that degrades HS in the extracellular matrix and basement membranes and is implicated in numerous pathological processes suc...

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Detalles Bibliográficos
Autores principales: Chhabra, Mohit, Wilson, Jennifer C., Wu, Liang, Davies, Gideon J., Gandhi, Neha S., Ferro, Vito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303737/
https://www.ncbi.nlm.nih.gov/pubmed/34981584
http://dx.doi.org/10.1002/chem.202104222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303737/
https://www.ncbi.nlm.nih.gov/pubmed/34981584
http://dx.doi.org/10.1002/chem.202104222

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