Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells

Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its half‐life. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid cells. Recent data suggest a role for properdin as a pattern r...

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Detalles Bibliográficos
Autores principales: van Essen, Mieke F., Schlagwein, Nicole, van den Hoven, Elisa M.P., van Gijlswijk‐Janssen, Daniëlle J., Lubbers, Rosalie, van den Bos, Ramon M., van den Born, Jacob, Ruben, Jurjen M., Trouw, Leendert A., van Kooten, Cees
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Molecular immunology and signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303752/
https://www.ncbi.nlm.nih.gov/pubmed/35092629
http://dx.doi.org/10.1002/eji.202149259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303752/
https://www.ncbi.nlm.nih.gov/pubmed/35092629
http://dx.doi.org/10.1002/eji.202149259

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