Structures of Silver Fingers and a Pathway to Their Genotoxicity

Recently, we demonstrated that Ag(I) can directly replace Zn(II) in zinc fingers (ZFs). The cooperative binding of Ag(I) to ZFs leads to a thermodynamically irreversible formation of silver clusters destroying the native ZF structure. Thus, a reported loss of biological function of ZF proteins is a...

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Detalles Bibliográficos
Autores principales: Kluska, Katarzyna, Veronesi, Giulia, Deniaud, Aurélien, Hajdu, Bálint, Gyurcsik, Béla, Bal, Wojciech, Krężel, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303758/
https://www.ncbi.nlm.nih.gov/pubmed/35041243
http://dx.doi.org/10.1002/anie.202116621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303758/
https://www.ncbi.nlm.nih.gov/pubmed/35041243
http://dx.doi.org/10.1002/anie.202116621

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