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In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contacts
VPS13 is a eukaryotic lipid transport protein localized at membrane contact sites. Previous studies suggested that it may transfer lipids between adjacent bilayers by a bridge-like mechanism. Direct evidence for this hypothesis from a full-length structure and from electron microscopy (EM) studies i...
Autores principales: | Cai, Shujun, Wu, Yumei, Guillén-Samander, Andrés, Hancock-Cerutti, William, Liu, Jun, De Camilli, Pietro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303930/ https://www.ncbi.nlm.nih.gov/pubmed/35858323 http://dx.doi.org/10.1073/pnas.2203769119 |
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