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Quantitative NMR analysis of the kinetics of prenucleation oligomerization and aggregation of pathogenic huntingtin exon-1 protein
The N-terminal region of the huntingtin protein, encoded by exon-1 (htt(ex1)) and containing an expanded polyglutamine tract, forms fibrils that accumulate in neuronal inclusion bodies, resulting in Huntington’s disease. We previously showed that reversible formation of a sparsely populated tetramer...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303973/ https://www.ncbi.nlm.nih.gov/pubmed/35858329 http://dx.doi.org/10.1073/pnas.2207690119 |