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Quantitative NMR analysis of the kinetics of prenucleation oligomerization and aggregation of pathogenic huntingtin exon-1 protein

The N-terminal region of the huntingtin protein, encoded by exon-1 (htt(ex1)) and containing an expanded polyglutamine tract, forms fibrils that accumulate in neuronal inclusion bodies, resulting in Huntington’s disease. We previously showed that reversible formation of a sparsely populated tetramer...

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Detalles Bibliográficos
Autores principales:	Ceccon, Alberto, Tugarinov, Vitali, Torricella, Francesco, Clore, G. Marius
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303973/ https://www.ncbi.nlm.nih.gov/pubmed/35858329 http://dx.doi.org/10.1073/pnas.2207690119

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