Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity

The dichotomous behavior of superoxide dismutase-2 (SOD2) in cancer biology has long been acknowledged and more recently linked to different posttranslational forms of the enzyme. However, a distinctive activity underlying its tumor-promoting function is yet to be described. Here, we report that ace...

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Detalles Bibliográficos
Autores principales: Coelho, Diego R., Palma, Flavio R., Paviani, Veronica, He, Chenxia, Danes, Jeanne M., Huang, Yunping, Calado, Juliana C. P., Hart, Peter C., Furdui, Cristina M., Poole, Leslie B., Schipma, Matthew J., Bonini, Marcelo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303987/
https://www.ncbi.nlm.nih.gov/pubmed/35858297
http://dx.doi.org/10.1073/pnas.2110348119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303987/
https://www.ncbi.nlm.nih.gov/pubmed/35858297
http://dx.doi.org/10.1073/pnas.2110348119

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