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Epithelial chemerin–CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase
Intestinal barrier immunity is essential for controlling gut microbiota without eliciting harmful immune responses, while its defect contributes to the breakdown of intestinal homeostasis and colitis development. Chemerin, which is abundantly expressed in barrier tissues, has been demonstrated to re...
Autores principales: | Lin, Yuli, Cai, Qian, Luo, Yaxin, Li, Bingji, Chen, Yu, Yang, Xuguang, Xuan, Yan, Yang, Huifan, He, Rui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304024/ https://www.ncbi.nlm.nih.gov/pubmed/35858331 http://dx.doi.org/10.1073/pnas.2205574119 |
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