H(2)S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine

Cystathionine beta-synthase (CBS) is a pivotal enzyme of the transsulfuration pathway responsible for diverting homocysteine to the biosynthesis of cysteine and production of hydrogen sulfide (H(2)S). Aberrant upregulation of CBS and overproduction of H(2)S contribute to pathophysiology of several d...

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Detalles Bibliográficos
Autores principales: Petrosino, Maria, Zuhra, Karim, Kopec, Jola, Hutchin, Andrew, Szabo, Csaba, Majtan, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304066/
https://www.ncbi.nlm.nih.gov/pubmed/35864237
http://dx.doi.org/10.1007/s00018-022-04479-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304066/
https://www.ncbi.nlm.nih.gov/pubmed/35864237
http://dx.doi.org/10.1007/s00018-022-04479-9

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