Electrostatic Perturbations in the Substrate‐Binding Pocket of Taurine/α‐Ketoglutarate Dioxygenase Determine its Selectivity

Taurine/α‐ketoglutarate dioxygenase is an important enzyme that takes part in the cysteine catabolism process in the human body and selectively hydroxylates taurine at the C(1)‐position. Recent computational studies showed that in the gas‐phase the C(2)−H bond of taurine is substantially weaker than...

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Detalles Bibliográficos
Autores principales: Ali, Hafiz Saqib, de Visser, Sam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304159/
https://www.ncbi.nlm.nih.gov/pubmed/34967481
http://dx.doi.org/10.1002/chem.202104167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304159/
https://www.ncbi.nlm.nih.gov/pubmed/34967481
http://dx.doi.org/10.1002/chem.202104167

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