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Electrostatic Perturbations in the Substrate‐Binding Pocket of Taurine/α‐Ketoglutarate Dioxygenase Determine its Selectivity
Taurine/α‐ketoglutarate dioxygenase is an important enzyme that takes part in the cysteine catabolism process in the human body and selectively hydroxylates taurine at the C(1)‐position. Recent computational studies showed that in the gas‐phase the C(2)−H bond of taurine is substantially weaker than...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304159/ https://www.ncbi.nlm.nih.gov/pubmed/34967481 http://dx.doi.org/10.1002/chem.202104167 |