Genetic Encoding of Cyanopyridylalanine for In‐Cell Protein Macrocyclization by the Nitrile–Aminothiol Click Reaction

Cyanopyridylalanines are non‐canonical amino acids that react with aminothiol compounds under physiological conditions in a biocompatible manner without requiring added catalyst. Here we present newly developed aminoacyl‐tRNA synthetases for genetic encoding of meta‐ and para‐cyanopyridylalanine to...

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Detalles Bibliográficos
Autores principales: Abdelkader, Elwy H., Qianzhu, Haocheng, George, Josemon, Frkic, Rebecca L., Jackson, Colin J., Nitsche, Christoph, Otting, Gottfried, Huber, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304162/
https://www.ncbi.nlm.nih.gov/pubmed/35102680
http://dx.doi.org/10.1002/anie.202114154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304162/
https://www.ncbi.nlm.nih.gov/pubmed/35102680
http://dx.doi.org/10.1002/anie.202114154

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