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Genetic Encoding of Cyanopyridylalanine for In‐Cell Protein Macrocyclization by the Nitrile–Aminothiol Click Reaction

Cyanopyridylalanines are non‐canonical amino acids that react with aminothiol compounds under physiological conditions in a biocompatible manner without requiring added catalyst. Here we present newly developed aminoacyl‐tRNA synthetases for genetic encoding of meta‐ and para‐cyanopyridylalanine to...

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Detalles Bibliográficos
Autores principales:	Abdelkader, Elwy H., Qianzhu, Haocheng, George, Josemon, Frkic, Rebecca L., Jackson, Colin J., Nitsche, Christoph, Otting, Gottfried, Huber, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304162/ https://www.ncbi.nlm.nih.gov/pubmed/35102680 http://dx.doi.org/10.1002/anie.202114154

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