Chloromethyl Glycosides as Versatile Synthons to Prepare Glycosyloxymethyl‐Prodrugs

This work investigates the addition of monosaccharides to marketed drugs to improve their pharmacokinetic properties for oral absorption. To this end, a set of chloromethyl glycoside synthons were developed to prepare a variety of glycosyloxymethyl‐prodrugs derived from 5‐fluorouracil, thioguanine,...

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Detalles Bibliográficos
Autores principales: Elferink, Hidde, Titulaer, Willem H. C., Derks, Maik G. N., Veeneman, Gerrit H., Rutjes, Floris P. J. T., Boltje, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304170/
https://www.ncbi.nlm.nih.gov/pubmed/35045197
http://dx.doi.org/10.1002/chem.202103910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304170/
https://www.ncbi.nlm.nih.gov/pubmed/35045197
http://dx.doi.org/10.1002/chem.202103910

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