Combining factor VIII levels and thrombin/plasmin generation: A population pharmacokinetic‐pharmacodynamic model for patients with haemophilia A

AIMS: Prophylactic treatment of haemophilia A patients with factor VIII (FVIII) concentrate focuses on maintaining a minimal trough FVIII activity level to prevent bleeding. However, due to differences in bleeding tendency, the pharmacokinetic (PK)‐guided dosing approach may be suboptimal. An altern...

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Detalles Bibliográficos
Autores principales: Bukkems, Laura H., Valke, Lars L. F. G., Barteling, Wideke, Laros‐van Gorkom, Britta A. P., Blijlevens, Nicole M. A., Cnossen, Marjon H., van Heerde, Waander L., Schols, Saskia E. M., Mathôt, Ron A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304184/
https://www.ncbi.nlm.nih.gov/pubmed/34921439
http://dx.doi.org/10.1111/bcp.15185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304184/
https://www.ncbi.nlm.nih.gov/pubmed/34921439
http://dx.doi.org/10.1111/bcp.15185

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