A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR

BACKGROUND AND PURPOSE: Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are small molecules developed to treat the genetic disease cystic fibrosis (CF). They interact directly with CFTR Cl(−) channels at the plasma membrane to enhance channel gating. Here, we investigate the...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Jia, Berg, Allison P., Wang, Yiting, Jantarajit, Walailak, Sutcliffe, Katy J., Stevens, Edward B., Cao, Lishuang, Pregel, Marko J., Sheppard, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304199/
https://www.ncbi.nlm.nih.gov/pubmed/34644413
http://dx.doi.org/10.1111/bph.15709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304199/
https://www.ncbi.nlm.nih.gov/pubmed/34644413
http://dx.doi.org/10.1111/bph.15709

Ejemplares similares