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A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR

BACKGROUND AND PURPOSE: Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are small molecules developed to treat the genetic disease cystic fibrosis (CF). They interact directly with CFTR Cl(−) channels at the plasma membrane to enhance channel gating. Here, we investigate the...

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Detalles Bibliográficos
Autores principales:	Liu, Jia, Berg, Allison P., Wang, Yiting, Jantarajit, Walailak, Sutcliffe, Katy J., Stevens, Edward B., Cao, Lishuang, Pregel, Marko J., Sheppard, David N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304199/ https://www.ncbi.nlm.nih.gov/pubmed/34644413 http://dx.doi.org/10.1111/bph.15709

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