Off‐target inhibition of NGLY1 by the polycaspase inhibitor Z‐VAD‐fmk induces cellular autophagy

The polycaspase inhibitor Z‐VAD‐fmk acts as an inhibitor of peptide: N‐glycanase (NGLY1), an endoglycosidase which cleaves N‐linked glycans from glycoproteins exported from the endoplasmic reticulum (ER) during ER‐associated degradation (ERAD). Both pharmacological N‐glycanase inhibition by Z‐VAD‐fm...

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Detalles Bibliográficos
Autores principales: Needs, Sarah H., Bootman, Martin D., Grotzke, Jeff E., Kramer, Holger B., Allman, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304259/
https://www.ncbi.nlm.nih.gov/pubmed/34995415
http://dx.doi.org/10.1111/febs.16345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304259/
https://www.ncbi.nlm.nih.gov/pubmed/34995415
http://dx.doi.org/10.1111/febs.16345

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