Biallelic and gene-wide genomic substitution for endogenous intron and retroelement mutagenesis in human cells

Functional annotation of the vast noncoding landscape of the diploid human genome still remains a major challenge of genomic research. An efficient, scarless, biallelic, and gene-wide mutagenesis approach is needed for direct investigation of the functional significance of endogenous long introns in...

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Detalles Bibliográficos
Autores principales: Ohno, Tomoyuki, Akase, Taichi, Kono, Shunya, Kurasawa, Hikaru, Takashima, Takuto, Kaneko, Shinya, Aizawa, Yasunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304424/
https://www.ncbi.nlm.nih.gov/pubmed/35864085
http://dx.doi.org/10.1038/s41467-022-31982-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304424/
https://www.ncbi.nlm.nih.gov/pubmed/35864085
http://dx.doi.org/10.1038/s41467-022-31982-1

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