The m(6)A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic β Cells by Regulating MafA Expression

Methylglyoxal, a major precursor of advanced glycation end products, is elevated in the plasma of patients with type 2 diabetes mellitus. Islet β-cell function was recently shown to be regulated by N(6)-methyladenosine (m(6)A), an RNA modification consisting of methylation at the N6 position of aden...

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Detalles Bibliográficos
Autores principales: Cheng, Yi, Yao, Xin-Ming, Zhou, Si-Min, Sun, Yue, Meng, Xiang-Jian, Wang, Yong, Xing, Yu-Jie, Wan, Shu-Jun, Hua, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304699/
https://www.ncbi.nlm.nih.gov/pubmed/35872977
http://dx.doi.org/10.3389/fendo.2022.910868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304699/
https://www.ncbi.nlm.nih.gov/pubmed/35872977
http://dx.doi.org/10.3389/fendo.2022.910868

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