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Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma

Ovarian clear cell carcinoma (OCCC) is an understudied poor prognosis subtype of ovarian cancer lacking in effective targeted therapies. Efforts to define molecular drivers of OCCC malignancy may lead to new therapeutic targets and approaches. Among potential targets are secreted proteases, enzymes...

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Detalles Bibliográficos
Autores principales: Mehner, Christine, Hockla, Alexandra, Coban, Mathew, Madden, Benjamin, Estrada, Rosendo, Radisky, Derek C., Radisky, Evette S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304776/
https://www.ncbi.nlm.nih.gov/pubmed/35716777
http://dx.doi.org/10.1016/j.jbc.2022.102146