Cargando…

Mapping interactions between the CRAC activation domain and CC1 regulating the activity of the ER Ca(2+) sensor STIM1

Stromal interaction molecule 1 (STIM1) is a widely expressed protein that functions as the endoplasmic reticulum (ER) Ca(2+) sensor and activator of Orai1 channels. In resting cells with replete Ca(2+) stores, an inhibitory clamp formed by the coiled-coil 1 (CC1) domain interacting with the CRAC-act...

Descripción completa

Detalles Bibliográficos
Autores principales: Shrestha, Nisha, Hye-Ryong Shim, Ann, Maneshi, Mohammad Mehdi, See-Wai Yeung, Priscilla, Yamashita, Megumi, Prakriya, Murali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304783/
https://www.ncbi.nlm.nih.gov/pubmed/35724962
http://dx.doi.org/10.1016/j.jbc.2022.102157