Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1–ClpP1P2 protease

The ring-forming AAA+ hexamer ClpC1 associates with the peptidase ClpP1P2 to form a central ATP-driven protease in Mycobacterium tuberculosis (Mtb). ClpC1 is essential for Mtb viability and has been identified as the target of antibacterial peptides like CyclomarinA (CymA) that exhibit strong toxici...

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Detalles Bibliográficos
Autores principales: Taylor, Gabrielle, Frommherz, Yannick, Katikaridis, Panagiotis, Layer, Dominik, Sinning, Irmgard, Carroni, Marta, Weber-Ban, Eilika, Mogk, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305358/
https://www.ncbi.nlm.nih.gov/pubmed/35768046
http://dx.doi.org/10.1016/j.jbc.2022.102202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305358/
https://www.ncbi.nlm.nih.gov/pubmed/35768046
http://dx.doi.org/10.1016/j.jbc.2022.102202

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