Rapid monitoring of high‐mannose glycans during cell culture process of therapeutic monoclonal antibodies using lectin affinity chromatography

We developed a simple high‐performance liquid chromatography assay to monitor high‐mannose glycans in monoclonal antibodies by monitoring terminal alpha‐mannose as a surrogate marker. Analysis of glycan data of therapeutic monoclonal antibodies by 2‐aminobenzamide assay showed a linear relationship...

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Detalles Bibliográficos
Autores principales: Kim, Jun, Albarghouthi, Methal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Liquid Chromatography
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305444/
https://www.ncbi.nlm.nih.gov/pubmed/35043561
http://dx.doi.org/10.1002/jssc.202100903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305444/
https://www.ncbi.nlm.nih.gov/pubmed/35043561
http://dx.doi.org/10.1002/jssc.202100903

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