Stereoselective Synthesis, Configurational Assignment and Biological Evaluations of the Lipid Mediator RvD2(n‐3 DPA)

Herein we report the first total synthesis of RvD2(n‐3 DPA), an endogenously formed mediator biosynthesized from the omega‐3 fatty acid n‐3 docosapentaenoic acid. The key steps are the Midland Alpine borane reduction, Sonogashira cross‐coupling reactions, and a Z‐selective alkyne reduction protocol,...

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Detalles Bibliográficos
Autores principales: Reinertsen, Amalie F., Primdahl, Karoline G., De Matteis, Roberta, Dalli, Jesmond, Hansen, Trond V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305452/
https://www.ncbi.nlm.nih.gov/pubmed/34890076
http://dx.doi.org/10.1002/chem.202103857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305452/
https://www.ncbi.nlm.nih.gov/pubmed/34890076
http://dx.doi.org/10.1002/chem.202103857

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