Cargando…
TSH receptor specific monoclonal autoantibody K1‐70(TM) targeting of the TSH receptor in subjects with Graves' disease and Graves' orbitopathy—Results from a phase I clinical trial
OBJECTIVES: In Graves' disease (GD), autoantibodies to the thyroid stimulating hormone receptor (TSHR) cause hyperthyroidism. The condition is often associated with eye signs including proptosis, oedema, and diplopia (collectively termed Graves' orbitopathy [GO]). The safety profile of K1‐...
Autores principales: | Furmaniak, Jadwiga, Sanders, Jane, Sanders, Paul, Li, Yang, Rees Smith, Bernard |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305464/ https://www.ncbi.nlm.nih.gov/pubmed/35088429 http://dx.doi.org/10.1111/cen.14681 |
Ejemplares similares
-
Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70(TM) a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity
por: Furmaniak, Jadwiga, et al.
Publicado: (2019) -
Practical applications of studies on the TSH receptor and TSH receptor autoantibodies
por: Furmaniak, J., et al.
Publicado: (2020) -
Blocking type TSH receptor antibodies
por: Furmaniak, Jadwiga, et al.
Publicado: (2012) -
Structure and activation of the TSH receptor transmembrane domain
por: Núñez Miguel, Ricardo, et al.
Publicado: (2016) -
Structure of full-length TSH receptor in complex with antibody K1-70™
por: Núñez Miguel, Ricardo, et al.
Publicado: (2022)