Cargando…

Understanding the Blood‐Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

This review addresses questions on how to accomplish successful central nervous system (CNS) drug delivery (i.e., having the right concentration at the right CNS site, at the right time), by understanding the rate and extent of blood‐brain barrier (BBB) transport and intra‐CNS distribution in relati...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Lange, Elizabeth C. M., Hammarlund Udenaes, Margareta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305478/ https://www.ncbi.nlm.nih.gov/pubmed/35220577 http://dx.doi.org/10.1002/cpt.2545

Ejemplares similares

The brain slice method for studying drug distribution in the CNS
por: Loryan, Irena, et al.
Publicado: (2013)

Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment
por: Hu, Yang, et al.
Publicado: (2020)

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017
por: Greenwood, John, et al.
Publicado: (2017)

Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017
por: Greenwood, John, et al.
Publicado: (2018)

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier
por: Luptáková, Dominika, et al.
Publicado: (2021)

Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro
por: Melander, Erik, et al.
Publicado: (2023)

On The Rate and Extent of Drug Delivery to the Brain
por: Hammarlund-Udenaes, Margareta, et al.
Publicado: (2007)

Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport
por: Sadiq, Muhammad Waqas, et al.
Publicado: (2015)

Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate
por: Melander, Erik, et al.
Publicado: (2016)

Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
por: Gustafsson, Sofia, et al.
Publicado: (2019)

Revisiting atenolol as a low passive permeability marker
por: Chen, Xiaomei, et al.
Publicado: (2017)

Beyond the Blood:Brain Barrier: The Importance of Central Nervous System (CNS) Pharmacokinetics for the Treatment of CNS Tumors, Including Diffuse Intrinsic Pontine Glioma
por: Warren, Katherine Elizabeth
Publicado: (2018)

Effect of transporter inhibition on the distribution of cefadroxil in rat brain
por: Chen, Xiaomei, et al.
Publicado: (2014)

Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview
por: Archie, Sabrina Rahman, et al.
Publicado: (2021)

Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy
por: Upton, Dannielle H., et al.
Publicado: (2022)

Characterizing the blood–brain barrier and gut barrier with super-resolution imaging: opportunities and challenges
por: Doney, Ellen, et al.
Publicado: (2023)

The Effects of Pharmacist Intervention on Emergency Department Visits in Patients 80 Years and Older: Subgroup Analyses by Number of Prescribed Drugs and Appropriate Prescribing
por: Alassaad, Anna, et al.
Publicado: (2014)

A tool for prediction of risk of rehospitalisation and mortality in the hospitalised elderly: secondary analysis of clinical trial data
por: Alassaad, Anna, et al.
Publicado: (2015)

Blood–Brain Barrier Transporters: Opportunities for Therapeutic Development in Ischemic Stroke
por: Nilles, Kelsy L., et al.
Publicado: (2022)

CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges
por: Hornung, Simon, et al.
Publicado: (2020)

Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier
por: Upadhyay, Ravi Kant
Publicado: (2014)

The Impairment of Blood-Brain Barrier in Alzheimer’s Disease: Challenges and Opportunities with Stem Cells
por: López-Ornelas, Adolfo, et al.
Publicado: (2022)

Novel Therapeutic Opportunities for Neurodegenerative Diseases with Mesenchymal Stem Cells: The Focus on Modulating the Blood-Brain Barrier
por: Vargas-Rodríguez, Pablo, et al.
Publicado: (2023)

Effects of Pharmacists' Interventions on Appropriateness of Prescribing and Evaluation of the Instruments' (MAI, STOPP and STARTs') Ability to Predict Hospitalization–Analyses from a Randomized Controlled Trial
por: Gillespie, Ulrika, et al.
Publicado: (2013)

Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS
por: Silva, Gabriel A
Publicado: (2008)

Blood‒Brain Barrier Pathology and CNS Outcomes in Streptococcus pneumoniae Meningitis
por: Yau, Belinda, et al.
Publicado: (2018)

A Unique Carrier for Delivery of Therapeutic Compounds beyond the Blood-Brain Barrier
por: Karkan, Delara, et al.
Publicado: (2008)

Endonasal CNS Delivery System for Blood-Brain Barrier Impermeant Therapeutic Oligonucleotides Using Heterotopic Mucosal Engrafting
por: Pawar, Grishma, et al.
Publicado: (2021)

Transgenic animal models to explore and modulate the blood brain and blood retinal barriers of the CNS
por: Goncalves, Andreia, et al.
Publicado: (2022)

Pretargeted imaging beyond the blood–brain barrier
por: Shalgunov, Vladimir, et al.
Publicado: (2022)

Modeling the blood-brain barrier for treatment of central nervous system (CNS) diseases
por: Rice, Olivia, et al.
Publicado: (2022)

Correction: A Unique Carrier for Delivery of Therapeutic Compounds beyond the Blood-Brain Barrier
por: Karkan, Delara, et al.
Publicado: (2008)

Correction: A Unique Carrier for Delivery of Therapeutic Compounds beyond the Blood-Brain Barrier
por: Karkan, Delara, et al.
Publicado: (2008)

Correction: A Unique Carrier for Delivery of Therapeutic Compounds beyond the Blood-Brain Barrier
por: Karkan, Delara, et al.
Publicado: (2008)

Cell Secretome: Basic Insights and Therapeutic Opportunities for CNS Disorders
por: Pinho, Andreia G., et al.
Publicado: (2020)

Autophagy in white matter disorders of the CNS: mechanisms and therapeutic opportunities
por: Nutma, Erik, et al.
Publicado: (2020)

Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier
por: Watson, P Marc D, et al.
Publicado: (2013)

Navigating the Blood–Brain Barrier: Challenges and Therapeutic Strategies in Breast Cancer Brain Metastases
por: Terceiro, Lucas E. L., et al.
Publicado: (2023)

Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier
por: Li, Jia, et al.
Publicado: (2021)

Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease
por: Ravenstijn, Paulien GM, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_a3oq9dbsp9cf0e3j3i1h0o2scl