Unlocking the Hydrolytic Mechanism of GH92 α‐1,2‐Mannosidases: Computation Inspires the use of C‐Glycosides as Michaelis Complex Mimics

The conformational changes in a sugar moiety along the hydrolytic pathway are key to understand the mechanism of glycoside hydrolases (GHs) and to design new inhibitors. The two predominant itineraries for mannosidases go via (O) S (2)→B (2,5)→(1) S (5) and (3) S(1) →(3) H (4)→(1) C (4). For the CAZ...

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Detalles Bibliográficos
Autores principales: Alonso‐Gil, Santiago, Parkan, Kamil, Kaminský, Jakub, Pohl, Radek, Miyazaki, Takatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305736/
https://www.ncbi.nlm.nih.gov/pubmed/35049087
http://dx.doi.org/10.1002/chem.202200148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305736/
https://www.ncbi.nlm.nih.gov/pubmed/35049087
http://dx.doi.org/10.1002/chem.202200148

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