Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries

Several lines of evidence suggest the ligand‐sensing transcription factor Nurr1 as a promising target to treat neurodegenerative diseases. Nurr1 modulators to validate and exploit this therapeutic potential are rare, however. To identify novel Nurr1 agonist chemotypes, we have employed the Nurr1 act...

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Detalles Bibliográficos
Autores principales: Willems, Sabine, Müller, Marcel, Ohrndorf, Julia, Heering, Jan, Proschak, Ewgenij, Merk, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305750/
https://www.ncbi.nlm.nih.gov/pubmed/35132775
http://dx.doi.org/10.1002/cmdc.202200026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305750/
https://www.ncbi.nlm.nih.gov/pubmed/35132775
http://dx.doi.org/10.1002/cmdc.202200026

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