IGF‐1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex‐specific manner

Insulin‐like growth factor‐I (IGF‐I) signaling plays a key role in neuroinflammation. Here we show that IGF‐1 also regulates phagocytosis of reactive astrocytes through p110α isoform of phosphatidylinositol 3‐kinase (PI3K), differentially in both sexes. Systemic bacterial lipopolysaccharide (LPS)‐tr...

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Detalles Bibliográficos
Autores principales: Pinto‐Benito, Daniel, Paradela‐Leal, Carmen, Ganchala, Danny, de Castro‐Molina, Paula, Arevalo, Maria‐Angeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305764/
https://www.ncbi.nlm.nih.gov/pubmed/35175663
http://dx.doi.org/10.1002/glia.24163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305764/
https://www.ncbi.nlm.nih.gov/pubmed/35175663
http://dx.doi.org/10.1002/glia.24163

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