Cargando…

IGF‐1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex‐specific manner

Insulin‐like growth factor‐I (IGF‐I) signaling plays a key role in neuroinflammation. Here we show that IGF‐1 also regulates phagocytosis of reactive astrocytes through p110α isoform of phosphatidylinositol 3‐kinase (PI3K), differentially in both sexes. Systemic bacterial lipopolysaccharide (LPS)‐tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pinto‐Benito, Daniel, Paradela‐Leal, Carmen, Ganchala, Danny, de Castro‐Molina, Paula, Arevalo, Maria‐Angeles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305764/ https://www.ncbi.nlm.nih.gov/pubmed/35175663 http://dx.doi.org/10.1002/glia.24163

Ejemplares similares

Kif21B mediates the effect of estradiol on the morphological plasticity of mouse hippocampal neurons
por: Ganchala, Danny, et al.
Publicado: (2023)

The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge
por: Crespo-Castrillo, Andrea, et al.
Publicado: (2020)

Aging and sex: Impact on microglia phagocytosis
por: Yanguas‐Casás, Natalia, et al.
Publicado: (2020)

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
por: Soler, Adriana, et al.
Publicado: (2013)

Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K
por: Okkenhaug, Klaus, et al.
Publicado: (2007)

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
por: Berenjeno, Inma M., et al.
Publicado: (2012)

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
por: Al-Qassab, Hind, et al.
Publicado: (2009)

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction
por: Konishi, Hiroyuki, et al.
Publicado: (2020)

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity
por: Buchanan, Christina M., et al.
Publicado: (2013)

Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ
por: Hassenrück, Floyd, et al.
Publicado: (2023)

Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia
por: Bucher, Kirsten, et al.
Publicado: (2017)

FGF2 modulates cardiac remodeling in an isoform- and sex-specific manner
por: Nusayr, Eyad, et al.
Publicado: (2013)

The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner
por: Menko, A. Sue, et al.
Publicado: (2022)

The Contribution of Astrocyte Autophagy to Systemic Metabolism
por: Ortiz-Rodriguez, Ana, et al.
Publicado: (2020)

PTEN regulated PI3K-p110 and AKT isoform plasticity controls metastatic prostate cancer progression
por: Miller, Karina, et al.
Publicado: (2023)

Profilin Isoforms Modulate Astrocytic Morphology and the Motility of Astrocytic Processes
por: Schweinhuber, Stefanie K., et al.
Publicado: (2015)

Nucleolar localization of an isoform of the IGF-I precursor
por: Tan, Daniel SW, et al.
Publicado: (2002)

Counteracting sarcopenia: the role of IGF-1 isoforms
por: Musarò, Antonio, et al.
Publicado: (2019)

Cardiac development and physiology are modulated by FGF2 in an isoform- and sex-specific manner
por: Nusayr, Eyad, et al.
Publicado: (2013)

The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1
por: Cain, Robert J., et al.
Publicado: (2010)

Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase
por: Guo, Yue, et al.
Publicado: (2022)

Astrocyte-Derived Thrombospondin Induces Cortical Synaptogenesis in a Sex-Specific Manner
por: Mazur, Anna, et al.
Publicado: (2021)

Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice
por: Wan, Ting, et al.
Publicado: (2022)

Diminished LC3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes
por: Wakida, Nicole M., et al.
Publicado: (2022)

IGF2 Mediates Resistance to Isoform-Selective-Inhibitors of the PI3K in HPV Positive Head and Neck Cancer
por: Badarni, Mai, et al.
Publicado: (2021)

$\pi$p->$\pi$ $\pi$ N reactions near threshold-80-110
por: CERN. Geneva. Proton Synchrotron and Synchrocyclotron Committee
Publicado: (1980)

Microglial and Astrocytic Function in Physiological and Pathological Conditions: Estrogenic Modulation
por: Crespo-Castrillo, Andrea, et al.
Publicado: (2020)

Effects of IGF‐1 isoforms on muscle growth and sarcopenia
por: Ascenzi, Francesca, et al.
Publicado: (2019)

Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition
por: Leroy, Cedric, et al.
Publicado: (2016)

Epigenetic modifier Kdm6a/Utx controls the specification of hypothalamic neuronal subtypes in a sex-dependent manner
por: Cabrera Zapata, Lucas E., et al.
Publicado: (2022)

Inhibition of PI3K Prevents the Proliferation and Differentiation of Human Lung Fibroblasts into Myofibroblasts: The Role of Class I P110 Isoforms
por: Conte, Enrico, et al.
Publicado: (2011)

AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury
por: Zhou, Hang, et al.
Publicado: (2021)

Potential role of insulin receptor isoforms and IGF receptors in plaque instability of human and experimental atherosclerosis
por: Beneit, Nuria, et al.
Publicado: (2018)

PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition
por: Zhao, Hua-Fu, et al.
Publicado: (2016)

Effect of combined inhibition of p110 alpha PI3K isoform and STAT3 pathway in ovarian cancer platinum-based resistance
por: Le Naour, Augustin, et al.
Publicado: (2018)

Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function
por: Moore, Samantha F., et al.
Publicado: (2019)

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors
por: Tsolakos, N., et al.
Publicado: (2018)

The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis
por: Sen, Monokesh K., et al.
Publicado: (2022)

IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer
por: Zorea, Jonatan, et al.
Publicado: (2018)

AMPK Regulates Circadian Rhythms in a Tissue- and Isoform-Specific Manner
por: Um, Jee-Hyun, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_mv0uovdjjeussaflbf7mhk78q8