Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses

BACKGROUND: Bintrafusp alfa (BA) is a bifunctional fusion protein designed for colocalized, simultaneous inhibition of two immunosuppressive pathways, transforming growth factor-β (TGF-β) and programmed death-ligand 1 (PD-L1), within the tumor microenvironment (TME). We hypothesized that targeting P...

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Detalles Bibliográficos
Autores principales: Lan, Yan, Yeung, Tsz-Lun, Huang, Hui, Wegener, Ansgar A, Saha, Somdutta, Toister-Achituv, Mira, Jenkins, Molly H, Chiu, Li-Ya, Lazorchak, Adam, Tarcic, Ohad, Wang, Hong, Qi, Jin, Locke, George, Kalimi, Doron, Qin, Guozhong, Marelli, Bo, Yu, Huakui, Gross, Alec W, Derner, Melissa G, Soloviev, Maria, Botte, Mathieu, Sircar, Aroop, Ma, Hong, Sood, Vanita D, Zhang, Dong, Jiang, Feng, Lo, Kin-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305820/
https://www.ncbi.nlm.nih.gov/pubmed/35858707
http://dx.doi.org/10.1136/jitc-2021-004122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305820/
https://www.ncbi.nlm.nih.gov/pubmed/35858707
http://dx.doi.org/10.1136/jitc-2021-004122

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