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The effect of dimerization and ligand binding on the dynamics of Kaposi's sarcoma‐associated herpesvirus protease

The Kaposi's sarcoma‐associated herpesvirus protease is essential for virus maturation. This protease functions under allosteric regulation that establishes its enzymatic activity upon dimerization. It exists in equilibrium between an inactive monomeric state and an active, weakly associating,...

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Detalles Bibliográficos
Autores principales: Bern, David, Tobi, Dror
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305915/
https://www.ncbi.nlm.nih.gov/pubmed/35084062
http://dx.doi.org/10.1002/prot.26307