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Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis

[Image: see text] RibB (3,4-dihydroxy-2-butanone 4-phosphate synthase) is a magnesium-dependent enzyme that excises the C4 of d-ribulose-5-phosphate (d-Ru5P) as formate. RibB generates the four-carbon substrate for lumazine synthase that is incorporated into the xylene moiety of lumazine and ultimat...

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Detalles Bibliográficos
Autores principales: Kenjić, Nikola, Meneely, Kathleen M., Wherritt, Daniel J., Denler, Melissa C., Jackson, Timothy A., Moran, Graham R., Lamb, Audrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305975/
https://www.ncbi.nlm.nih.gov/pubmed/35802469
http://dx.doi.org/10.1021/jacs.2c03376