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Poly(a) selection introduces bias and undue noise in direct RNA-sequencing
BACKGROUND: Genome-wide RNA-sequencing technologies are increasingly critical to a wide variety of diagnostic and research applications. RNA-seq users often first enrich for mRNA, with the most popular enrichment method being poly(A) selection. In many applications it is well-known that poly(A) sele...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306060/ https://www.ncbi.nlm.nih.gov/pubmed/35869428 http://dx.doi.org/10.1186/s12864-022-08762-8 |