Engineering Enzyme‐Cleavable Oligonucleotides by Automated Solid‐Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers

Oligonucleotides containing cleavable linkers have emerged as versatile tools to achieve stimulus‐responsive and site‐specific cleavage of DNA. However, the limitations of previously reported cleavable linkers including photolabile and disulfide linkers have restricted their applications in vivo. In...

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Detalles Bibliográficos
Autores principales: Jin, Cheng, EI‐Sagheer, Afaf H., Li, Siqi, Vallis, Katherine A., Tan, Weihong, Brown, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306542/
https://www.ncbi.nlm.nih.gov/pubmed/34953094
http://dx.doi.org/10.1002/anie.202114016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306542/
https://www.ncbi.nlm.nih.gov/pubmed/34953094
http://dx.doi.org/10.1002/anie.202114016

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