A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands, New Drug Leads and PROTACs

A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein‐coupled receptors (GPCRs). Starting from vercirnon, an intracellular C−C chemokine receptor type 9 (CCR9) antagonist and previous phase III clinical candidate for the treatment of Crohn's...

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Detalles Bibliográficos
Autores principales: Huber, Max E., Toy, Lara, Schmidt, Maximilian F., Vogt, Hannah, Budzinski, Julian, Wiefhoff, Martin F. J., Merten, Nicole, Kostenis, Evi, Weikert, Dorothee, Schiedel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306553/
https://www.ncbi.nlm.nih.gov/pubmed/34936714
http://dx.doi.org/10.1002/anie.202116782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306553/
https://www.ncbi.nlm.nih.gov/pubmed/34936714
http://dx.doi.org/10.1002/anie.202116782

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