Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA‐Displayed Peptide Libraries

DNA‐encoded small‐molecule libraries and mRNA displayed peptide libraries both use numerically large pools of oligonucleotide‐tagged molecules to identify potential hits for protein targets. They differ dramatically, however, in the ‘drug‐likeness’ of the molecules that each can be used to discover....

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Detalles Bibliográficos
Autores principales: Melsen, Paddy R. A., Yoshisada, Ryoji, Jongkees, Seino A. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306583/
https://www.ncbi.nlm.nih.gov/pubmed/35100479
http://dx.doi.org/10.1002/cbic.202100685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306583/
https://www.ncbi.nlm.nih.gov/pubmed/35100479
http://dx.doi.org/10.1002/cbic.202100685

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