Loss of a newly discovered microRNA in Chinese hamster ovary cells leads to upregulation of N‐glycolylneuraminic acid sialylation on monoclonal antibodies

Chinese hamster ovary (CHO) cells are known not to express appreciable levels of the sialic acid residue N‐glycolylneuraminic acid (NGNA) on monoclonal antibodies. However, we actually have identified a recombinant CHO cell line expressing an IgG with unusually high levels of NGNA sialylation (>3...

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Detalles Bibliográficos
Autores principales: Fischer, Simon, Mathias, Sven, Stadermann, Anna, Yang, Shumin, Schmieder, Valerie, Zeh, Nikolas, Schmidt, Nicoletta, Richter, Patrick, Wright, Sara, Zimmermann, Eike, Ley, Yan, van der Meer, Julia, Hartsch, Thomas, Bernloehr, Christian, Otte, Kerstin, Bradl, Harald, Gamer, Martin, Schulz, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306616/
https://www.ncbi.nlm.nih.gov/pubmed/34935124
http://dx.doi.org/10.1002/bit.28015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306616/
https://www.ncbi.nlm.nih.gov/pubmed/34935124
http://dx.doi.org/10.1002/bit.28015

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