A model‐based analysis to guide gonadotropin‐releasing hormone receptor antagonist use for management of endometriosis

AIMS: To identify linzagolix doses, an oral GnRH receptor antagonist, that effectively lower oestradiol (E2) to relieve endometriosis‐related pelvic pain without compromising bone health. METHODS: Integrated statistical, pharmacokinetic–pharmacodynamic and systems pharmacology models were developed...

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Detalles Bibliográficos
Autores principales: Pohl, Oliver, Baron, Kyle, Riggs, Matthew, French, Jonathan, Garcia, Ramon, Gotteland, Jean‐Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306723/
https://www.ncbi.nlm.nih.gov/pubmed/34904270
http://dx.doi.org/10.1111/bcp.15171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306723/
https://www.ncbi.nlm.nih.gov/pubmed/34904270
http://dx.doi.org/10.1111/bcp.15171

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