Asymmetric Synthesis of Heterocyclic Chloroamines and Aziridines by Enantioselective Protonation of Catalytically Generated Enamines

We report a method for the synthesis of chiral vicinal chloroamines via asymmetric protonation of catalytically generated prochiral chloroenamines using chiral Brønsted acids. The process is highly enantioselective, with the origin of asymmetry and catalyst substituent effects elucidated by DFT calc...

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Detalles Bibliográficos
Autores principales: McLean, Liam A., Ashford, Matthew W., Fyfe, James W. B., Slawin, Alexandra M. Z., Leach, Andrew G., Watson, Allan J. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306946/
https://www.ncbi.nlm.nih.gov/pubmed/35133031
http://dx.doi.org/10.1002/chem.202200060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306946/
https://www.ncbi.nlm.nih.gov/pubmed/35133031
http://dx.doi.org/10.1002/chem.202200060

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