Pharmacokinetics and Macrophage Inhibitory Cytokine‐1 Pharmacodynamics of the Murine Double Minute 2 Inhibitor, Navtemadlin (KRT‐232) in Fed and Fasted Healthy Subjects

This single 60‐mg dose, 4‐period crossover study assessed the effect of food and formulation change on navtemadlin (KRT‐232) pharmacokinetics (PK) and macrophage inhibitory cytokine‐1 (MIC‐1) pharmacodynamics. Healthy subjects (N = 30) were randomized to 3 treatment sequences, A: new tablet, fasted...

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Detalles Bibliográficos
Autores principales: Wong, Shekman, Krejsa, Cecile, Lee, Dana, Harris, Anna, Simard, Emilie, Wang, Xiaohui, Allard, Martine, Podoll, Terry, O'Reilly, Terry, Slatter, J. Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306949/
https://www.ncbi.nlm.nih.gov/pubmed/35172043
http://dx.doi.org/10.1002/cpdd.1070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306949/
https://www.ncbi.nlm.nih.gov/pubmed/35172043
http://dx.doi.org/10.1002/cpdd.1070

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