Effect of Roxadustat on the Pharmacokinetics of Simvastatin, Rosuvastatin, and Atorvastatin in Healthy Subjects: Results From 3 Phase 1, Open‐Label, 1‐Sequence, Crossover Studies

Roxadustat inhibits breast cancer resistance protein and organic anion transporting polypeptide 1B1, which can affect coadministered statin concentrations. Three open‐label, 1‐sequence crossover phase 1 studies in healthy subjects were conducted to assess effects from steady‐state 200‐mg roxadustat...

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Detalles Bibliográficos
Autores principales: Groenendaal‐van de Meent, Dorien, den Adel, Martin, Kerbusch, Virginie, van Dijk, Jan, Shibata, Tomohisa, Kato, Kota, Schaddelee, Marloes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306950/
https://www.ncbi.nlm.nih.gov/pubmed/35182045
http://dx.doi.org/10.1002/cpdd.1076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306950/
https://www.ncbi.nlm.nih.gov/pubmed/35182045
http://dx.doi.org/10.1002/cpdd.1076

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