Estimation of nizatidine gastric nitrosatability and product toxicity via an integrated approach combining HILIC, in silico toxicology, and molecular docking

The liability of the H(2)-receptor antagonist nizatidine (NZ) to nitrosation in simulated gastric juice (SGJ) and under WHO-suggested conditions was investigated for the first time. For monitoring the nitrosatability of NZ, a hydrophilic interaction liquid chromatography (HILIC) method was optimized...

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Detalles Bibliográficos
Autores principales: El-Shaheny, Rania, Radwan, Mohamed, Yamada, Koji, El-Maghrabey, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306978/
https://www.ncbi.nlm.nih.gov/pubmed/31590763
http://dx.doi.org/10.1016/j.jfda.2019.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306978/
https://www.ncbi.nlm.nih.gov/pubmed/31590763
http://dx.doi.org/10.1016/j.jfda.2019.08.001

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